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  • 產(chǎn)品名稱(chēng)：Pim-1Oncogene(PIM1)(N-Term)Peptide

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Pim-1Oncogene(PIM1)(N-Term)Peptide
詳情介紹：
Blocked Antibody anti-PIM1 antibody (Pim-1 Oncogene) (N-Term) (ABIN2786676)
Sequence MLLSKINSLA HLRAAPCNDL HATKLAPGKE KEPLESQYQV GPLLGSGGFG
Characteristics This is a synthetic peptide designed for use in combination with anti-PIM1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).

Alias Symbols: PIM

Protein Size: 313
Molecular Weight 36 kDa
Gene ID 5292
NCBI Accession NM_001243186, NP_001230115
Research Area Hematopoietic Progenitors, Cancer
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100?μL of sterile PBS. Final peptide concentration is 1?mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.