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Background
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Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG) stored in cellular lipid droplets by essential TAG hydrolase named adipose triglyceride lipase (ATGL). The ATGL action generates non-esterified fatty acids, which are subsequently used as energy substrate, essential precursors for lipid and membrane synthesis and mediator of cell signaling molecules. ATGL activity is regulated by several enzymes and binding factors including ATGL activator patatin-like phospholipase domain containing protein 58 (alpha/beta hydrolase containing protein 5) and ATGL inhibitor G0/G1 switch gene 2 (G0S2). Other factors/enzymes include hormone sensitive lipase E, and mono glyceride lipase constitute the basic \ |
