產(chǎn)品詳情

  • 產(chǎn)品名稱：AMG-47a

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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AMG-47a
詳情介紹：
Purpose AMG-47a is a potent inhibitor of Lck and T cell proliferation
Characteristics AMG-47a is a potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED?? = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. In several other in vitro assays, AMG-47 displays subnanomolar inhibition against Lck, and low (<10 10="" nm)="" inhibition="" against="" other="" hard="" to="" inhibit="" kinases="" such="" as="" kdr="" and="" src="" mapk="" α="" (p38α).="" in="" addition,="" at="" slightly="" higher="" doses="" but="" well="" under="" μm,="" amg-47="" effectively="" inhibits="" the="" jnk="" family="" of="" including="" tyk2="" ~="" 1.2="" μm.="" <="" td="">
Purity ≥ 98?% by HPLC
Chemical Name 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide
Formula C??H??F?N?O?
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 535.56 g/mol
CAS-No 882663-88-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months