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Purpose
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A potent, highly selective, ATP-competitive PIKfyve inhibitor
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Characteristics
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APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC?? = 5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. Also acts as a unique small molecular IL-12/23 production inhibitor.
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Purity
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≥ 98?% by HPLC
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Chemical Name
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(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine
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Formula
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C??H??N?O
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Permeability
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Cell-permeable
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Solubility
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DMSO (>30 mg/ml)
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