|
Purpose
|
A specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity.
|
|
Characteristics
|
ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing phosphorylation of the pro-apoptotic amino alcohol spingosine to spingosine-1-phosphate (S1P), the lipid mediator that is important for immunomodulation, this phosphorylation prevention of amino alcohol can induce apoptosis and may inhibit cancer cell proliferation.
|
|
Purity
|
≥ 98?% by HPLC
|
|
Chemical Name
|
1S,3R,5R,7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
|
|
Formula
|
C??H??ClN?O
|
|
Permeability
|
Cell-permeable
|
|
Solubility
|
DMSO(>4 mg/ml)
|
