Characteristics
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AM-095 is a potent LPA1 receptor antagonist with IC?? values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibitsLPA-driven chemotaxis of CHO cells overexpressing mouse LPA? (IC?? = 778 nM) and human A2058 melanoma cells (IC?? = 233 nM).
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