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  • 產(chǎn)品名稱：Alpelisib

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  • 產(chǎn)品廠商：Biovision
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Alpelisib
詳情介紹：
Purpose A potent and selective phosphatidylinositol-3 kinase α inhibitor
Characteristics Alpelisib (also known as BYL719), is a potent and selective phosphatidylinositol-3 kinase α inhibitor. It inhibits P110α, p110β, p110δ, and p110g with IC?? values of 5 nM, 1.2 μM, 0.29 μM and 0.25 μM, respectively, in biochemical assays. It inhibits the Akt phosphorylation with IC?? values of 74 nM in Rat1-myr-p110α cells, 2.2 μM in Rat1-myr-p110β cells, and 1.2 μM in Rat1-myr-p110δ cells.
Purity ≥ 98?% by HPLC
Chemical Name (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide; BYL719
Formula C??H??F?N?O?S
Permeability Cell-permeable
Molecular Weight 441.47 g/mol
CAS-No 1217486-61-7
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months