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  • 產(chǎn)品名稱：Caspase-8InhibitorZ-IETD-FMK

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  • 產(chǎn)品廠商：Biovision
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Caspase-8InhibitorZ-IETD-FMK
詳情介紹：
Purpose A caspase-8 inhibitor
Sequence Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Characteristics PubChem CID: 44135212
A synthetic peptide that irreversibly inhibits FLICE and related protease/caspase activity and blocks apoptosis. IETD is the specific recognition sequence found in CPP32 proenzyme. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.)
Purity > 99?% by HPLC
Chemical Name Z-IETD-FMK, Caspase-8 Inhibitor, Z-IETD-fluoromethylketone
Formula C??H??FN?O??
Permeability Cell-permeable
Solubility DMSO
Molecular Weight 654.7 g/mol
Application Notes We recommend using 5000X dilutions for inhibiting caspase-8 activity in Jurkat cell culture (e.g., Add 1 l to 5 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
Restrictions For Research Use only
Format Liquid
Concentration 10 mM
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 12 months
Supplier Images
image for Caspase-8 Inhibitor Z-IETD-FMK (ABIN412376) Caspase-8 Inhibitor Z-IETD-FMK
Product cited in: Westphal, Sytnyk, Schachner, Leshchynska: "Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8- and -3-dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth." in: The Journal of biological chemistry, Vol. 285, Issue 53, pp. 42046-57, 2010 (PubMed).

Tang, Liu, Wang, Wang, Cao, Mi, Zhang: "Involvement of caspase 8 in apoptosis induced by ultrasound-activated hematoporphyrin in sarcoma 180 cells in vitro." in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, Vol. 27, Issue 4, pp. 645-56, 2008 (PubMed).

Deng, Yin, Lu, Cai, Yin: "The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 91, Issue 1, pp. 59-69, 2006 (PubMed).

Teachey, Obzut, Axsom, Choi, Goldsmith, Hall, Hulitt, Manno, Maris, Rhodin, Sullivan, Brown, Grupp: "Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)." in: Blood, Vol. 108, Issue 6, pp. 1965-71, 2006 (PubMed).

Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).

Song, Mahidhara, Zhou, Hoffman, Seol, Flavell, Billiar, Otterbein, Choi: "Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 2, pp. 1220-6, 2004 (PubMed).

Song, Zhou, Kim, Shapiro, Liu, Ferran, Choi, Otterbein: "Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44327-34, 2004 (PubMed).

Wang, Grégori, Hullinger, Andrisani et al.: "Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor ..." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10352-65, 2004 (PubMed).

Yen, Mar, Craciunescu, Edwards, Zeisel: "Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells." in: The Journal of nutrition, Vol. 132, Issue 7, pp. 1840-7, 2002 (PubMed).

Frost, Delikat, Al-Mehairi, Sinclair: "Regulation of p27KIP1 in Epstein-Barr virus-immortalized lymphoblastoid cell lines involves non-apoptotic caspase cleavage." in: The Journal of general virology, Vol. 82, Issue Pt 12, pp. 3057-66, 2001 (PubMed).