產(chǎn)品詳情

  • 產(chǎn)品名稱：AG-120(Ivosidenib)

  • 產(chǎn)品型號(hào)：
  • 產(chǎn)品廠商：Biovision
  • 產(chǎn)品文檔：
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AG-120(Ivosidenib)
詳情介紹：
Purpose AG-120 (Ivosidenib)
Characteristics AG-120 is a potent isocitrate dehydrogenase type 1 (IDH1) inhibitor, with potential antineoplastic activity. Upon oral administration it specifically inhibits a mutated form of IDH1 in the cytoplasm inhibiting the formation of oncometabolite, 2-hydroxyglutarate (2HG). This leads to induction of cellular differentiation and an inhibition of cellular proliferation
Purity ≥ 98?% by HPLC
Chemical Name (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
Formula C??H??ClF?N?O?
Permeability Cell-permeable
Solubility DMSO (>5 mg/ml))
Molecular Weight 582.97 g/mol
CAS-No 1448346-63-1
Restrictions For Research Use only
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months