產(chǎn)品詳情

  • 產(chǎn)品名稱：Mouseanti-ChickenIgMAntibody

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  • 產(chǎn)品廠商：Acris-antibodies
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Mouseanti-ChickenIgMAntibody
詳情介紹：
Clone M-1
Isotype IgG2b
Purification Purified
Background IgM normally constitutes about 10?% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.Synonyms: Chicken Immunoglobulin M
Research Area Secondary Antibodies, Immunology
Application Notes Flow Cytometry. Immunoprecipitation.

Other applications not tested.
Otimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer 100 mM Borate Buffered Saline,?pH 8.2. No preservatives or amine-containing buffer salts added.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -28 °C for longer.
Background publications Chen, Lehmeyer, Cooper: "Evidence for an IgD homologue on chicken lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 129, Issue 6, pp. 2580-5, 1983 (PubMed).